TIP of the Week: New inflammation tests predict heart attacks

HeartHawk
By HeartHawk Latest Reply 2012-08-28 22:30:46 -0500
Started 2012-06-20 21:03:27 -0500

The prestigious Cleveland Clinic, known for its advanced heart programs, recently released a new battery of heart-related inflammation tests that add predictive value for both long-term and near-term heart attack risk. The concept is so novel it was featured in the cutting edge TED symposiums. You can see the YouTube video here.

http://www.heartconnect.com/videos/79-marc-pe...

The battery of tests include:

Myeloperoxidase (MPO)
Lipoprotein-Associated Phospholipase A2 (LP-PLA2)
High-Sensitivity C-Reactive Protein (hsCRP)
Urinary Microalbumin
F2 Isoprostanes (F2 IsoP's)

You may also reference an article on the subject found at

http://www.heartconnect.com/news-articles/659...

What would be most helpful to our community is to hear from members who have had one or more of these tests and what your docs have offered as suggestions to treat high test results for one or more of these tests. Can anyone help or provide insight and/or experience? Anyone even heard of these tests?

HH


4 replies

RedSun
RedSun 2012-08-28 11:22:58 -0500 Report

I tried printing the actual article so that I could bring it to my cardiologist but it will not print no matter what I do.

HeartHawk
HeartHawk 2012-08-28 22:30:46 -0500 Report

Red:

Here, just print this!

Understanding Inflammation Testing

As featured at TEDMED 2012

Cleveland HeartLab has established a profile of biomarkers that measure both oxidation and inflammation levels in order to help better define individuals at risk and also to determine where they are on a spectrum of risk. In short, this profile of biomarkers enables physicians to determine who is at risk and why they are at risk.

Using five simple, non-invasive tests, physicians can determine if an individual:

• Is early in the disease process and may someday have disease
• Has disease, but it’s not actively progressing
• Has disease that is actively progressing putting them at risk for a heart attack or stroke

Myeloperoxidase (MPO)
MPO is a white blood cell-derived inflammatory enzyme that is used by the immune system to fight infection. Interestingly, white blood cells also release MPO when responding to damaged arteries in an attempt to mend the body. In these instances, white blood cells may respond to vulnerable plaque, erosions or a tear in the artery wall and release MPO into the bloodstream. Thus, MPO levels in the bloodstream are a specific marker of white blood cell activity in response to vulnerable plaque or erosions, and can determine your risk for heart attack.

Lp-PLA2 (The PLAC® Test)
Lp-PLA2 is a vascular-specific inflammatory enzyme that is predominantly attached LDL (low-density lipoprotein; “bad” cholesterol). When the artery wall is damaged due to high blood pressure or smoking, the Lp-PLA2-LDL complex enters the artery wall. Here, Lp-PLA2 modifies the LDL releasing byproducts which cause inflammation, and ultimately lead to plaque accumulation in the artery wall. Thus, Lp-PLA2 levels can be used to measures the amount of vulnerable plaque, and determine risk for heart attack or stroke.

High-Sensitivity CRP (hsCRP)
C-reactive protein (CRP) is an acute phase protein released by the liver during systemic inflammation. The high-sensitivity CRP test is a sensitive way to measure small amounts of CRP. Because inflammation underlies the atherosclerotic process, CRP can be used as an indirect measure of heart disease and identify risk for heart attack and stroke.

Microalbumin
Microalbumin detects small amounts of albumin, a serum protein, in the urine that is below the detection limit of a standard dipstick test. Because albumin is not normally present in the urine, but retained in the bloodstream by the kidneys, microalbumin can be used to measure microvascular integrity and endothelial dysfunction as early indicators of heart disease.

F2-Isoprostanes
F2-Isoprostanes are potent inflammatory mediators and markers of oxidative stress formed from the peroxidation of essential fatty acids. F2-Isoprostanes are considered lifestyle markers that are indicative of diet and exercise patterns that may contribute to the premature development of disease.

HH

Perplexed
Perplexed 2012-06-22 00:39:50 -0500 Report

Microalbumin
Microalbumin detects small amounts of albumin, a serum protein, in the urine that is below the detection limit of a standard dipstick test. Because albumin is not normally present in the urine, but retained in the bloodstream by the kidneys, microalbumin can be used to measure microvascular integrity and endothelial dysfunction as early indicators of heart disease.

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