Multaq (dronedarone) Not Good For Permanent A Fib

Perplexed
By Perplexed Latest Reply 2011-07-13 17:50:29 -0500
Started 2011-07-08 06:10:36 -0500

A randomized trial of dronedarone (Multaq) in patients with permanent atrial fibrillation — an unapproved indication for the antiarrhythmic drug — has been stopped early because of increased cardiovascular events among patients receiving the product, its manufacturer said.

Dronedarone, sold by sanofi-aventis, is currently approved to treat atrial flutter and paroxysmal or persistent — but not permanent — afib.

http://www.medpagetoday.com/Cardiology/Arrhyt...


10 replies

HeartHawk
HeartHawk 2011-07-13 09:58:36 -0500 Report

Perplexed,

While travelling in Europe I have been keeping my eyes open for articles in Europe pertinent to our discussions. Seems Like the European Medicines Agency (EMA), the equivalent to US FDA, now has doubts about using Multaq in permanent AF patients.

Here is the article:

http://www.heartconnect.com/news-articles/280-ema-adds-cv-events-to-review-of-dronedarone

HH

Perplexed
Perplexed 2011-07-13 10:50:51 -0500 Report

Thanks, HeartHawk. Its good of you to investigate EMA's policies about Multaq. Have you also kept an eye on any differences between EMA and FDA stands on other cardiac and A fib meds, etc?

HeartHawk
HeartHawk 2011-07-13 17:50:29 -0500 Report

Perplexed,

Looks like it is similar - extreme caution without directly banning it. Not a good sign! Kind of a politically correct way of saying "don't prescribe it!"

HH

Perplexed
Perplexed 2011-07-09 08:03:00 -0500 Report

Thanks, HeartHawk. I have paroxysmal A fib and am on Rythmol and Toprol (and coumadin, of course) and doing fine since the third day of Rythmol (other then coumadin dosage) so truthfully haven't stayed too abreast of research in this field. I haven't found any of the arrhythmia forums very busy so don't check them as regularly as I suppose I should.

HeartHawk
HeartHawk 2011-07-10 08:15:37 -0500 Report

Perplexed,

Thanks, more good info sharing!

Did they start you propafenone (Rythmol) while under ECG monitoring? I am also curious as to what dosing was prescribed (100mg, three times a day)?

HH

Perplexed
Perplexed 2011-07-10 09:01:12 -0500 Report

They put me on a 3 week eCardio event monitor when starting the Rythmol. And it is the Rythmol SR 225 mg. I told him that I flat out would NOT stay on a 3 or 4 x a day dosing regimen of any medication. I just plain forget. Twice a day is the best I can do. So I take 225 mg 2 x daily. I dropped it to 225 mg 1 x daily for about a week but my lungs were acting up a bit at the time (I have COPD) so I went back on the 2 x a day dosing for the time being. I see him again in a week or so. Its been 6 months since I last saw him. But, of course, I am in regular contact w/his nurse due to the fun we are having w/the coumadin dosing.

HeartHawk
HeartHawk 2011-07-11 02:01:39 -0500 Report

Perplexed,

Yeah, that sounds right. I think 900mg is the maximum daily dose so half that makes sense. Ditto on the divided dosing. Most people (including me) have trouble taking stuff more than once a day let alone twice or three times.

Heh, one time my INR got close to 2 and they asked if I was on Coumadin (I'm not). It was probably the fish oil and aspirin, lol!

Hasta luego (until later)!

HH

Still in Spain!

HeartHawk
HeartHawk 2011-07-13 10:32:16 -0500 Report

Perplexed,

Heh, thanks! I think I am enjoying it too much. That Cuban rum they import here really sneaks up on you! "Me puse pedo" is similar to an equally colorful English expression for "I got drunk!" I was fine that evening but the next day I had one heck of a headache. Oh well, hopefully it will raise my HDL, lol!

HH

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