Like "I was put on metformin about 7 years ago after controlling my diabetes for 15 years without medicine but diet and exercise. They had stopped working which is why the doctor added metformin. I have not had any problems with it at alll and I take 1000 mg twice a day. I also was prescribed glimperide and januvia 2 years ago which are helping to protect the other organs as well as help with the diabetes. So far so good as none have shown any side affects."